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KMID : 0358119990250010072
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Journal of the Korean Public Health Association
1999 Volume.25 No. 1 p.72 ~ p.82
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The Seroprevalence and Risk Factors of Helicobacter pylori Infection
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Lee Hoo-Rak
Kim Yeung-Wook
Kim Don-Kyoun
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Abstract
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Helicobacter pylori is now recognized as a causative agent of chronic gastritis and peptic ulcer, and strongly associated with the development of gastric carcinoma. By the sensitive and specific serologic tests to identify the individuals infected with Helicobacter pylori, the epidemiologic features of this diseases have been investigated. But its transmission route is not establish, yet. The purpose of this study is to estimate the prevalence of Helicobacter pylori infection in health children and adults and to evaluate the risk factors for Helicobacter pylori infection in Korea.
The observed overall seropositivity rate, as determined by detecting IgG antibodies to Helicobacter pylori by using ELISA, was 33.1% and the age adjusted standardized prevalence rate was 51.5%. Also, age adjusted sex-specific standardized prevalence rates were 49.8% in male and 53.7% in female.
The prevalence rate was increased progressively from 10.0% in the age group 1∼9 years to 76.1% in the age group above 60 years(χ2 for trend=460, p<0.001). Especially, the rate increased abruptly from 6.3% in the age group 4∼6 years to 13.8% in the age group 7∼9 years, and this suggested that elementary school age would be the beginning time of Helicobacter pylori infection in good earnest.
In case of age group 1∼19 years, age and the numbers of family member in the house were statistically significant risk factors for Helicobacter pylori infection in multivariate logistic regression model. Especially, adjusted odds ratio(95% CI) for Helicobacter pylori infection in the age group 16∼19 years referent to age group 1∼3 years was 7.1(1.9-26.3), so age was the strongest predictive factor for Helicobacter pylori infection. In case of age group more than 20 years, age and number of family members were statistically significant risk factors for Helicobacter pylori infection in multivarite logistic regression model.
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KEYWORD
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risk factors of H. pylori infection, Seroprevalence, numbers of family member, age
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